At Lianhe Aigenis, we are at the forefront of PROTAC Linker Pharma Services, supporting the innovative development of Proteolysis Targeting Chimeras (PROTACs). These groundbreaking small molecules offer a novel approach to drug discovery by leveraging the cell’s natural degradation pathways to target and eliminate disease-causing proteins. Through our dedicated ADC/PROTAC Linker Platform, we provide comprehensive solutions for linker design, synthesis, and manufacturing, enabling the next generation of targeted therapeutics.

The Role of Linkers in PROTACs

Linkers are a crucial component of PROTACs, serving as a molecular bridge between the ligand that binds to the target protein and the ligand that recruits an E3 ubiquitin ligase. A well-designed linker ensures optimal spatial orientation, stability, and activity, directly influencing the efficacy and pharmacokinetics of the PROTAC molecule.

Our PROTAC Linker Services and Capabilities

1. Custom Linker Design and Development:

Expertise in designing linkers tailored to specific PROTAC applications, including rigid, flexible, hydrophobic, and hydrophilic linkers.

Optimization of linker length, polarity, and chemical properties to enhance degradation efficiency and drug-like behavior.

2. Advanced R&D Platforms:

ADC/PROTAC Linker Platform: A dedicated platform for developing versatile linker technologies, ensuring compatibility with a broad range of ligands and target proteins.

Access to cutting-edge tools for molecular modeling, synthesis, and in vitro testing.

3. GMP Manufacturing and Scale-Up:

Flexible production capabilities to support projects from early-stage R&D to commercial manufacturing.

GMP-certified facilities adhering to international quality standards, including FDA, EMA, and PMDA regulations.

4. Comprehensive Analytical Support:

Advanced analytical techniques for linker characterization, including purity, stability, and structural integrity assessments.

Tools like LC-MS, NMR, and HPLC for detailed quality analysis and regulatory compliance.

5. Regulatory and Technical Expertise:

Full support for IND, DMF, and regulatory submissions to facilitate clinical and commercial approval processes.

Collaborative problem-solving to address complex challenges in linker development.

6. Integrated Development Solutions:

Collaborative services to integrate linker design with ligand optimization and PROTAC molecule assembly.

Scalable solutions for seamless transition between preclinical, clinical, and commercial production stages.

Applications of PROTAC Linker Services

Our PROTAC linker solutions enable breakthroughs in therapeutic areas such as:

- Oncology: Targeting undruggable cancer proteins for degradation.

- Neurodegenerative Diseases: Removal of misfolded or toxic proteins in Alzheimer’s and Parkinson’s diseases.

- Autoimmune Disorders: Selective degradation of disease-associated proteins for immune regulation.

Partner with Lianhe Aigenis for PROTAC Innovations

Lianhe Aigenis is committed to advancing PROTAC drug discovery through cutting-edge linker technologies, robust manufacturing capabilities, and unwavering quality standards. As your trusted partner, we empower your research and development efforts with tailored solutions that accelerate innovation and bring transformative therapies to patients worldwide.