We have accumulated extensive experiences in modified nucleosides and nucleotides synthesis. Among them, phosphorylation reagents, ribose 2'-position modified monomers by fluorination and alkoxylation can be produced on a large scale. We have developed a stable and efficient production process for GalNAc, a nucleic acid drug delivery vehicle, with high yield and simple purification. In addition, the structure & production can be optimized according to the needs of customers.